Indian Journal of Pathology and Oncology

Official Publication of Innovative Education and Scientific Research Foundation


Current Issue

ISSN (Print): 2394-6784

Online ISSN: 2394-6792

CODEN: IJPOF3

About: Indian Journal of Pathology and Oncology (IJPO) is an open access, peer-reviewed medical quarterly journal, published since 2014 under the auspices of the Innovative Education and Scientific Research Foundation (IESRF), which aims to uplift researchers, scholars, academicians, and professionals in more...

Current Issue Highlights
Editorial
Revisiting RDW — Why RDW-SD deserves greater attention in routine hematology
Author details: Vineet Banga
Indian Journal of Pathology and Oncology. 12(3):228-229, 2025.
DOI: 10.18231/j.ijpo.26719.1760682732
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Review Article
Trastuzumab deruxtecan in breast cancer: Current status and future directions
Author details: Praloy Basu
Indian Journal of Pathology and Oncology. 12(3):230-234, 2025.
DOI: 10.18231/j.ijpo.12466.1759818827
Breast cancer is the most prevalent malignancy in women globally, with HER2-positive disease constituting approximately 15–20% of cases. The advent of HER2-targeted therapies has significantly improved outcomes; however, therapeutic resistance in metastatic settings remains a challenge. Trastuzumab....
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Original Article
Study of lesions of prostate after surgery and its correlation with PSA level and expression of p504s IHC marker in malignant lesions of prostate
Author details: Geetika Agarwal, Deepak Mittal, Deepali Gupta, Hemant Kumar, Divya Pursnani, Tanmeet Kaur, Asmita .
Indian Journal of Pathology and Oncology. 12(3):335-340, 2025.
DOI: 10.18231/j.ijpo.10788.1620688092
Background: Prostate lesions encompass a spectrum of benign and malignant pathologies, with prostate-specific antigen (PSA) serving as a key biomarker in their evaluation. Immunohistochemical (IHC) markers, such as α-methylacyl-CoA racemase (P504S), have emerged as adjuncts in distinguishing maligna....
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Multifaceted central nervous system metastases: An analysis of the clinicopathologic spectrum
Author details: Manveen Kaur, RPS Punia, Pooja Sharma, Ranjeev Bhagat, Phiza Aggarwal, Uma Handa, Vipin Gupta
Indian Journal of Pathology and Oncology. 12(3):241-246, 2025.
DOI: 10.18231/j.ijpo.12113.1759303083
Background: Central nervous system (CNS) metastases are the most common causes of neurologic abnormalities in patients with systemic malignancies. They can often be the initial manifestations of an undetected primary elsewhere.Materials and Methods: This is a retrospective study which included 55 pa....
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Association of serum prolactin levels with benign and malignant breast conditions and its utility as a predictor of breast cancer
Author details: Pavani Vatsal, Ashish Kumar Chaudhary, Vikash Katiar, Lubna Khan, Jitendra Kumar Verma, Yogendra Narayan Verma, Priyesh Shukla1
Indian Journal of Pathology and Oncology. 12(3):247-252, 2025.
DOI: 10.18231/j.ijpo.12959.1760415900
Background: The global burden of breast cancer is increasing, and it has become the most common malignancy in the female sex worldwide with increasing incidence of young onset breast cancer. Cheap and effective screening modalities are needed to reduce the mortality and morbidity associated with the....
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A study of endometrial biopsies with clinico-radiological and histopathological correlates at a tertiary care center
Author details: Bimal Patel, Jaydip Gorani
Indian Journal of Pathology and Oncology. 12(3):253-257, 2025.
DOI: 10.18231/j.ijpo.12851.1760415476
Background: Endometrial biopsies are important gynaecological diagnostic tool which helps understand endometrial pathology, particularly in the context of menorrhagia and abnormal uterine bleeding (AUB).Aim and Objectives: To study and correlate endometrial biopsies with clinical presentations, age....
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Case Series
Borderline phyllodes tumor – A saga of recurrences and malignant transformation
Author details: Neelam Sood, Ruhi .
Indian Journal of Pathology and Oncology. 12(3):258-266, 2025.
DOI: 10.18231/j.ijpo.12006.1759139906
Background: Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms with variable biological behaviour. While most cases are benign, some recur with increasing aggressiveness and histologic transformation. This study evaluates a case series of borderline phyllodes tumors from last 10....
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Plasma cell rich effusions and its concurrence with plasma cell neoplasms- A case series
Author details: Kirthi Nath K V, Soumya Satheesh, Aardra Rageesh
Indian Journal of Pathology and Oncology. 12(3):267-270, 2025.
DOI: 10.18231/j.ijpo.12809.1760416186
Plasma cell neoplasms are clonal hematologic malignancies that represent 10% of all hematologic neoplasms. Incidence increases with advancing age and early diagnosis is rewarding due to great treatment amenability. Diagnosis of this malignancy requires a combination of clinical, biochemical, immunoe....
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Case Report
Myofibroblastoma, a case report of uncovering this rare mesenchymal tumor
Author details: Sheelashree Ajakkala Narayana, Tahera Syed, Kiran Kumar Nayak S
Indian Journal of Pathology and Oncology. 12(3):271-274, 2025.
DOI: 10.18231/j.ijpo.11493.1746998923
A pathologist stumbles upon a male breast lump not uncommonly.Through the present case report, we uncover one of the rare breast tumors that every pathologist should be aware of, as it is often mistaken for a malignant lesion which in turn leads to radical treatment. To complicate things, this tumor....
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Cholesterotic fibrous histiocytoma (CFH): A case report
Author details: Supriya Mehrotra, Bandana Mehrotra, Sanjay Mehrotra, Ashok Kumar Kapoo, Hari Shyam
Indian Journal of Pathology and Oncology. 12(3):275-278, 2025.
DOI: 10.18231/j.ijpo.11334.1720918526
An elderly male patient complained of a small nodule, measuring 0.3 cm³ in right upper eye-lid. Microscopically, it showed chronic inflammation. Aggregates of cholesterol crystals were seen. Several multinucleate giant cells were also seen. The patient had persistently raised hyperlipoproteinemia wh....
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Rare meets routine: A case of sessile serrated lesion presenting as acute appendicitis
Author details: Syed Mubid Ali, Mohammed Abdullah Masood, Naushaba Tazeen, Asiya Tabassum, Idrees Akhtar Afroze, Atiya Begum, Shireen Adeeb Mujtaba Ali
Indian Journal of Pathology and Oncology. 12(3):279-282, 2025.
DOI: 10.18231/j.ijpo.11098.1680662831
Sessile serrated lesions (SSLs) are rare premalignant neoplasms usually arising in the colon but can also occur in the appendix, where their presentation often mimics acute appendicitis. We report the case of a 68‑year‑old male who presented with right lower abdominal pain and imaging findings sugge....
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Disseminated histoplasmosis in an elderly patient clinically mimicking a metastatic malignancy
Author details: Beant Kaur, Aparajita Goel
Indian Journal of Pathology and Oncology. 12(3):283-285, 2025.
DOI: 10.18231/j.ijpo.11058.1673781542
Histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, is endemic in parts of India and often manifests in immunocompromised individuals. However, its presentation can mimic malignancy, particularly in elderly patients, making timely diagnosis challenging. We report a case of a 55-ye....
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Low-grade sinonasal non-intestinal type adenocarcinoma (Non-ITAC): A rare case report
Author details: Vishalaxi H Patil, Sameer P Ahamed, Soumya BM, Rashmi P, Vardendra Kulkarni
Indian Journal of Pathology and Oncology. 12(3):286-289, 2025.
DOI: 10.18231/j.ijpo.51587.1760700391
Low-grade non-intestinal type sinonasal adenocarcinoma (SNAC) is a rare heterogenous group of tumours, distinct from intestinal and salivary type neoplasm. Low-grade type have more favourable prognosis compared to aggressive high grade. We report a case of low-grade non -intestinal type SNAC in a 50....
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Myopericytoma (MPC) of oral cavity in a 7-year-old child: A case report
Author details: Supriya Mehrotra, Bandana Mehrotra, Sanjay Mehrotra1, Ashok Kumar Kapoor, Hari Shyam
Indian Journal of Pathology and Oncology. 12(3):290-292, 2025.
DOI: 10.18231/j.ijpo.10672.1604238977
A patient aged 7 years complained of right-sided nasal premolar maxillary pain and nasal obstruction. He was operated. Post-operative recovery was normal. Histopathological examination revealed tumor tissue. Tumor consisted of interlacing bundles of proliferated tumor cells. Tumor cells had elongate....
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Appendiceal neuroendocrine tumors (ANETs)- incidental finding on frozen section of hysterectomy specimen
Author details: Ridham ., Amit Aggarwal, Anish Bhatia, Davinder Paul, Shivani Garg
Indian Journal of Pathology and Oncology. 12(3):293-295, 2025.
DOI: 10.18231/j.ijpo.7872.1069174083
Appendiceal neuroendocrine tumors (ANETs) occur in less than 1% of surgical resections. Grossly it is difficult to differentiate malignant tumor from benign conditions and clinically patients often present as asymptomatic or with symptoms like lower abdominal pain, nausea, vomiting etc. Present scen....
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Neurological fallout of mycophenolate: A PRES case
Author details: Jenny Susan Varghis, Sara Kurien Kodiattu, Chepsy C Philip, Aakash Chozakade, Bobby Abraham, Jacob Jesurun R S
Indian Journal of Pathology and Oncology. 12(3):296-299, 2025.
DOI: 10.18231/j.ijpo.12902.1759820304
Posterior reversible encephalopathy syndrome (PRES) is a rare, neurological disorder characterized by visual disturbances, altered mental status, seizures, and radiographic evidence of ‘cacogenic’ cerebral edema. It is most often associated with hypertensive crises, renal failure, and immunosuppress....
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ALK-positive large B-cell lymphoma presenting as oropharyngeal mass: A rare case report
Author details: Kavitha Bali Nagendrappa, Ramakrishna Reddy, Kalyan Rao, Reshma Stanly, Rajesh Bendre
Indian Journal of Pathology and Oncology. 12(3):300-303, 2025.
DOI: 10.18231/j.ijpo.12230.1759139552
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ LBCL) is an exceedingly rare and aggressive subtype of diffuse large B-cell lymphoma characterized by distinctive clinical and immunophenotypic features. It predominantly affects younger individuals and often presents with extranodal in....
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Malignant hidradenoma of the nasal tip mimicking basal cell carcinoma: A diagnostic pitfall
Author details: Awani Shrivastava, Nitish Baisakhiya, Ankita Baghel, Shilpi Parihar, Apoorva Shakti
Indian Journal of Pathology and Oncology. 12(3):304-307, 2025.
DOI: 10.18231/j.ijpo.12637.1759817306
Malignant hidradenoma is a rare eccrine sweat gland tumor, most commonly occurring in the head and neck, followed by the extremities; however, involvement of the nasal tip is exceptionally uncommon. These tumors typically present as slow-growing, painless nodules and can mimic more common cutaneous....
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Pediatric tumors with multilayered rosettes: a diagnostic dilemma: A rare case of Astroblastoma in a 2-year-old child
Author details: Neha Jain, Anshul Singh, Kachnar Verma, Pankaj Gupta
Indian Journal of Pathology and Oncology. 12(3):308-312, 2025.
DOI: 10.18231/j.ijpo.10711.1611780072
Background: Diagnosing pediatric CNS tumors with multilayered rosettes can be challenging due to its extreme rarity. Spectrum includes Astroblastomas, Ependymomas, Embryonal tumors with multilayered rosettes which share similar histomorphological features despite being molecularly distinct. Here, we....
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