Mukhopadhyay, Mukhopadhyay, Das, and Mukhopadhyay: Unusual renal tumor in an infant


Introduction

Renal Teratoma is very rare.1 All teratomas arise from the germ cell layer. Teratoma is a special type of tumor that contains recognizable mature and immature cells or tissues derived from one or more of the three primordial germ cell layers.2 The most common site of teratoma is the sacrococcygeal region. 40% of teratomas are found here., 25% occur in ovary followed by mediastinum, neck, brain and least common in the abdomen.3 Thirty cases of renal teratoma have been reported.4 Recently we came across an unusual renal tumor which we are describing.

Case History

A female baby aged two months weighing 2950 gm came with swelling in the left loin. The swelling was not noticed during birth. She had no other complaints other than the swelling. The loin mass was ballotable and measured (8cmx6cm). All other investigations e.g full blood count, blood sugar, urea, creatinine, serum bilirubin, urine examination were within normal limits.

The ultrasound examination of the abdomen showed a solid mass within the renal parenchyma. Contrast CT showed a solid heterogenous mass measuring (7cmx5.5cm) in the left kidney. (Figure 1) Areas of calcification were also evident. FNAC was done. It showed mature neural tissue, squamous cell, fat cell along with a few oval to spindle-shaped cells with focal atypia. The cytological diagnosis was mature teratoma.

Figure 1

CT scan showing solid heterogenous mass in left kidney

https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/a8b83d64-3790-451a-8967-95160f64899a/image/19646894-452d-4e01-8a11-42bec8e35265-uimage.png

The excision of Renal mass was done. The mass measured (7.5cmx6cmx5cm). (Figure 2) Cut surface showed that it was solid and it had variegated appearance. Cartilaginous areas and brain tissue-like areas were also present. Sections from various areas were taken. Microscopically there was mature squamous epithelium with hair follicle along with hair shaft, mature cartilage, neuroepithelial tissue, immature neural tube, (Figure 3) meningothelial cells, choroid plexus, neuroblastoma, and ganglioneuroblastoma like areas benign intestinal glands, but no areas of tubule formation, glomerulus formation blastemal cell and nephrogenic rests were noted. The histological diagnosis was Immature Teratoma. The patient was given Platinum-based chemotherapy. After three months the patient again returned with pain abdomen. CT showed an enlarged hilar lymph node. The lymph node was excised immediately and sent for histopathological examination. The lymph node was 3cmx2.5cm in size. The cut surface was white and solid. Histopathological examination revealed squamous epithelium with adnexal structures, areas of neuroblastoma, ganglioneuroblastoma, and small cyst-like areas lined by columnar epithelium with effacement of lymph nodal architecture. The diagnosis of metastasis from the Primary tumor was made. Again Platinum-based chemotherapy was given. The patient is doing well to date.

Figure 2

Cut surface of the kidney tumor

https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/a8b83d64-3790-451a-8967-95160f64899a/image/ed5e4e37-3bde-4ab3-981f-1e6f9d1e969e-uimage.png

Figure 3

The histopathology sections show immature neural tubule. (H&E, 400X)

https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/a8b83d64-3790-451a-8967-95160f64899a/image/ecd4d9ce-1f4b-4d1e-b71b-531af4869ae6-uimage.png

Discussion

Teratoma in children is uncommon. The incidence is 0.7 in 100000.5

Twenty cases of renal teratoma were reviewed by Choi et al. Among these cases 12 cases occurred in children and 8 cases were found in adults.15 cases were diagnosed as Immature teratoma and the male: female ratio was 1:1.4.6 After the report of twelve, cases of teratoma another mature teratoma of the kidney was reported in 2010.1 In our study the patient was female and it was an immature renal teratoma.

Patients with renal teratoma usually present with abdominal mass, pain abdomen, hematuria, vomiting.7 In our case, the abdominal swelling was the main complaint.

A radiological investigation like chest x-ray shows calcification and sometimes teeth.8 In our case contrast, CT showed calcification.

In 90% of teratoma of pediatric age group consists of components of all three germ cell layer.9

In our case, the tissue components of all three germ cell layers were also present. Histopathological examination of the specimen showed squamous epithelium with hair follicle, hair shaft, neuroepithelial tissue, fat cell, intestinal glands, choroid plexus, and meningothelial cells.

Rarely tumors are found in the retroperitoneal region, cervical region, mediastinal and intracranial region.10 But they did not report any case of Renal teratoma.

Immature tissues are seen in 20% to 40% of pediatric teratomas.11 In our case, we got immature renal tubules.

In the series of 92 cases of teratoma described by Amit V Varma et al., The commonest site was the ovary followed by the sacrococcygeal region, brain/spinal cord, mediastinum, and testis. They did not have any case of renal teratoma.12

There are several hypotheses regarding the origin of Teratoma like a) Germ cell theory b) the embryonic-cell theory; c) the unifying hypothesis; (iv) the extra-embryonic-cell theory; (v) the induced-twin hypothesis; and (vi) the fetus-in-fetus theory.13 The presence of displaced germ cells into the kidney may be suggested by the proximal location of the genital ridge to the nephrogenic anlage during embryogenesis.14 Few cases of renal teratoma were found to be associated with renal dysplasia, which may suggest that intrarenal teratoma is associated with development.

For diagnosis of renal teratoma following things must be established.

  1. The tumor should be of intrarenal in origin and no other teratomas in the body.

  2. The tumor should have evidence of forming of organs other than the kidney.15

The intrarenal origin was confirmed by CT. There was no tumor in gonads and any other retroperitoneal tumor. So it was not any metastasis from gonads or any extension from any retroperitoneal tumor. There was also no evidence of Teratoid Wilm The differential diagnosis include Teratoid Wilms, Mesoblastic Nephroma, neuroblastoma. These can be differentiated by histological examination.3

Teratomas are divided into mature and immature types. Well-differentiated tissues like dermal appendages, skin, neurological tissue, and teeth are found in Mature Teratoma while immature teratoma has similar histological features as fetal and embryonic tissue containing mature epithelium and immature areas of neuroectodermal and mesenchymal tissue. Mature teratomas are, usually, benign. No case of metastasis from mature Renal Teratoma has not been reported so far. Malignant potential is more in children presenting an early age as compared to older children. 11

Conclusion

Renal teratoma is an extremely uncommon tumor in infancy. But it is one of the differential diagnoses of renal mass in infants. Diagnosis may be suspected from radiological investigation and confirmed by histopathological examination. A good prognosis can be expected after proper management.

Source of Funding

None.

Conflict of Interest

The authors declare that there is no conflict of interest.

References

1 

M Mukhopadhyay Renal teratoma with duplication of cecum and appendixJ Pediatr Surg2010452558

2 

Robbins & Cotran Pathologic Basis of Disease10th edition2021269

3 

K Idrissi-Serhrouchni H El-Fatemi A madi K Benhayoun L Chbani T Harmouch Primary renal teratoma: a rare entityDiagn Pathol20138110710.1186/1746-1596-8-107

4 

H Hamidi N Foladi Intrarenal teratoma within a horseshoe kidney—A case reportRadiol Case Rep2020151743610.1016/j.radcr.2020.07.013

5 

A Moll A Krenauer U Bierbach H Till W Hirsch I Leuschner Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challengeDiagn Pathol2009413710.1186/1746-1596-4-37

6 

DJ Choi EC Wallace AE Fraire D Baiyee Best cases from the AFIP: Intrarenal teratomaRadiographics2005254815

7 

S Jacob D Ghosh P Rawat W Bhatti VP Singh Primary intra-renal teratoma associated with renal dysplasia: An unusual entityIndian J Surg201375779

8 

A Chaudhary S Misra A Wakhlu RK Tandon AK Wakhlu Retroperitoneal teratomas in childrenIndian J Pediatr2006733221310.1007/bf02825485

9 

H Isaacs Perinatal (congenital and neonatal) neoplasms: a report of 110 casesPediatr Pathol198532-416521610.3109/15513818509078782

10 

WF Partlow H Taybi Teratomas in infants and childrenAm J Roentgenol197111211556610.2214/ajr.112.1.155

11 

J Modi D Modi M Bachani L Bachani Congenital Renal Teratoma with Cystic Dysplasia in a Neonate: Rare EntityJ Clin Neonatol201542

12 

G Malpani AV Varma P Agrawal K Malukani S Dosi Clinicopathological spectrum of teratomas: An 8-year retrospective study from a tertiary care instituteIndian J Cancer2017543576910.4103/ijc.ijc_294_17

13 

F Gonzales-Crussi Extragonadal Teratomas2nd editionArmed Forces Institute of PathologyWashington, DC1984

14 

NM Jones EM Kiely Retroperitoneal teratomas—potential for surgical misadventureJ Pediatr Surg2008431184710.1016/j.jpedsurg.2007.09.041

15 

JB Beckwith Wilms' tumor and other renal tumors of childhood: A selective review from the National Wilms' Tumor Study Pathology CenterHum Pathol19831464819210.1016/s0046-8177(83)80003-3



jats-html.xsl

© This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


  • Article highlights
  • Article tables
  • Article images

Article History

Received : 18-06-2021

Accepted : 29-06-2021

Available online : 14-08-2021


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.ijpo.2021.079


Article Metrics






Article Access statistics

Viewed: 132

PDF Downloaded: 62



Wiki in hindi