Non-Hodgkin lymphomas – T cell type: Histomorphology and immunohistochemistry


Author Details : Priavadhana Rajan Prasaad*, Bhawana Ashok Badhe

Volume : 5, Issue : 4, Year : 2018

Article Page : 636-641


Suggest article by email

Abstract

Introduction: Non-Hodgkin lymphomas (NHL) comprise a wide variety of neoplasms and are subdivided into two main categories of low grade and high grade lymphomas. The major subtypes among T cell lymphomas are Peripheral T cell lymphomas – Not otherwise specified, Anaplastic Large cell lymphoma, ALK positive, Angioimmunoblastic T-cell lymphoma, T lymphoblastic leukemia/lymphoma and Extranodal NK/T cell lymphoma, nasal type. In this study, the histomorphological diagnostic features and the adjunct immunohistochemical expression of various markers are studied in a tertiary care centre in South India.
Materials and Methods: Patients with lymphadenopathy over a period of two years were included in the study. Lymph nodes excised from these patients were routinely processed and examined. After initial examination with H&E stain, appropriate special stains like Reticulin stain, Periodic Acid Schiff stain and Ziehl-Neelsen stains are performed along with the specific Immunohistochemical markers.
Results: A total of 30 cases were classified as Non-Hodgkin Lymphoma, high grade, T cell type. Peripheral T cell lymphomas-NOS is found to be the most common tumors accounting for 40% of all high grade T cell NHLs. The next common tumor was Anaplastic Large Cell Lymphoma, ALK positive with 36% of cases. T lymphoblastic leukemia/lymphoma accounted for 10% of cases and the rest of the cases were reported as Angioimmunoblastic T-cell lymphoma (7%) and Extranodal NK/T cell lymphoma, nasal type (7%).
Conclusion: Appropriate use of immunohistochemistry aids in the sub-classification of lymphomas according to the recommendations of WHO 2008. But, further molecular studies should be performed for confirmation of the subtyping done by immunohistochemistry.

Keywords: High grade lymphoma, Anaplastic large cell lymphoma, Peripheral T cell lymphoma.


How to cite : Prasaad P R, Badhe B A, Non-Hodgkin lymphomas – T cell type: Histomorphology and immunohistochemistry. Indian J Pathol Oncol 2018;5(4):636-641


Copyright © 2018 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)



View Article

PDF File  


Copyright permission

Get article permission for commercial use

Downlaod

PDF File    


Digital Object Identifier (DOI)

Article DOI

10.18231/2394-6792.2018.0121


Article Metrics






Article Access statistics

Viewed: 654

PDF Downloaded: 272