- Visibility 48 Views
- Downloads 37 Downloads
A rare case of Anaplastic Large Cell Lymphoma
- Author Details:
-
Nidhi Mahajan
-
Isha Gupta
-
Anshul Sharma
-
Kanav Gupta
Anaplastic large cell lymphoma is defined by a proliferation of large pleomorphic blasts and a constant expression of the CD30 molecule on all neoplastic cells, and has been clinically subdivided into a primary form and a secondary form. We are presenting a case of 54 year old male with multiple nodular lesions and a small non healing ulcer on it over left thigh along with inguinal lymphadenopathy since 3 months. Clinically the patient was diagnosed as Squamous Cell Carcinoma. FNAC from the lymphnode was done and cytodiagnosis of poorly differentiated malignancy was given. However due to presence of few atypical cell, FNAC was done from skin nodule and diagnosis was given as poorly differented malignancy suspicious of anaplastic large cell lymphoma. Confirmation was done by skin biopsy and immunochemistry, tumor cells were positive for CD30,CD 3(focal) and Granzyme B.
Keywords: ALK, CD30, Embyro shaped nucleus, Granzyme B, Immunohistochemistry
References
- Swerdlow S, Campo E, Harris N, et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 2008; 4th ed. Lyon, France, IARC Press. Nidhi Mahajan et al. 475 Indian Journal of Pathology and Oncology, July-September 2017;4(3):473-475
- Stein H, Foss HD, Durkop H, et al: CD30(+) anaplastic large cell lymphoma: A review of its histopathologic, genetic, and clinical features. Blood;2000;96:3681-3695.
- Tiodorovic J, Lazarevic V, Stanojevic M, et al: Anaplastic large cell Lymphoma. Arch Oncol 2006;14(1- 2):54-56.
- Kumar S, Pittaluga S, Raffeld M, et al: Primary cutaneous CD30-positive anaplastic large cell lymphoma in childhood: Report of 4 cases and review of the literature. Pediatr Dev Pathol;2005;8:52-60.
- Bekkenk MW, Geelen FA, van Voorst Vader PC, et al: Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: A report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Blood;2000;95:3653-3661.
- Willemze R, Jaffe ES, Burg G, et al: WHO-EORTC classification for cutaneous lymphomas. Blood;2005;105:3768-3785.
- Woo DK, Jones CR, Vanoli-Storz MN, et al: Prognostic factors in primary cutaneous anaplastic large cell lymphoma: Characterization of clinical subset with worse outcome. Arch Dermatol;2009;145:667-674.
- Savage KJ, Harris NL, Vose JM, et al: ALK- anaplastic large-cell lymphoma is clinica lly and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: Report from the International Peripheral T-Cell Lymphoma Project. Blood;2008;111:5496-5504.
- Takahashi D, Nagatoshi Y, Nagayama J, et al: Anaplastic large cell lymphoma in leukemic presentation: A case report and a review of the literature. J Pediatr Hematol Oncol;2008;30:696-700.
How to Cite This Article
Vancouver
Mahajan N, Gupta I, Sharma A, Gupta K. A rare case of Anaplastic Large Cell Lymphoma [Internet]. Indian J Pathol Oncol. 2017 [cited 2025 Oct 06];4(3):473-475. Available from: https://doi.org/
APA
Mahajan, N., Gupta, I., Sharma, A., Gupta, K. (2017). A rare case of Anaplastic Large Cell Lymphoma. Indian J Pathol Oncol, 4(3), 473-475. https://doi.org/
MLA
Mahajan, Nidhi, Gupta, Isha, Sharma, Anshul, Gupta, Kanav. "A rare case of Anaplastic Large Cell Lymphoma." Indian J Pathol Oncol, vol. 4, no. 3, 2017, pp. 473-475. https://doi.org/
Chicago
Mahajan, N., Gupta, I., Sharma, A., Gupta, K.. "A rare case of Anaplastic Large Cell Lymphoma." Indian J Pathol Oncol 4, no. 3 (2017): 473-475. https://doi.org/