Neuroendocrine carcinoma admixed adenocarcinoma of cervix: A case report of young female

Case Report

Author Details : Lal Chand Mittal*

Volume : 8, Issue : 4, Year : 2021

Article Page : 500-502

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Neuroendocrine carcinoma coexisted with adenocarcinoma in cervix is very rare. This disease has a very poor prognosis and so far no standard treatment has been obtained. A 35-years-old woman seeks medical attention with chief complaint of bleeding per vagina outside of menstruation. Ultrasound shows cervical mass of 4.2 cm × 2.9 cm. Microscopic biopsy suggestive of a mixture of neuroendocrine cervical carcinoma and adenocarcinoma, moderate-poor differentiation. Several immunohistochemical staining of the biopsy tissue was done to detect neuroendocrine and adenocarcinoma. In biopsy tissue, P63 immunohistochemical staining was performed to detect squamous cell carcinoma with negative results. Furthermore chromogranin, synaptophycin, CD 56, NSE, and P40 immunohistochemical staining were performed to detect neuroendocrine with positive results and so did CK 19, CEA, and CK 7 staining to detect positive adenocarcinomas. This rare case had a positive immunohistochemical staining of both neuroendocrine carcinoma and adenocarcinoma cervix. Patient received definitive concurrent chemo-radiotherpay.

Keywords: Neuroendocrine carcinoma, Adenocarcinoma cervix, Immunohistochemical.

How to cite : Mittal L C, Neuroendocrine carcinoma admixed adenocarcinoma of cervix: A case report of young female. Indian J Pathol Oncol 2021;8(4):500-502

Copyright © 2021 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 22-07-2021

Accepted : 19-08-2021

Available online : 23-11-2021

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