Histomorphological spectrum of intracranial space occupying lesions: Experience at tertiary care centre

Original Article

Author Details : Devika S Kinkhede, Saroj A Meshram*, Sanjay N Parate, Dinkar T Kumbhalkar, Shilpa P Tathe, Archana A Randale

Volume : 8, Issue : 4, Year : 2021

Article Page : 485-491


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Context: An “Intra-cranial space occupying lesion” (ICSOL) is defined as a mass in the cranial cavity with a diverse etiology like benign or malignant neoplasm, inflammatory or parasitic lesion, haematoma or arterio-venous malformation.
Aims: The aim was to study the histomorphological spectrum of intracranial space occupying lesions at a tertiary care centre hospital in order to give accurate pretherapeutic diagnosis to facilitate better therapeutic results.
Setting and Design: This prospective and descriptive type of study of two years duration was carried out from November 2017 to October 2019 in Govt. Medical College and Superspeciality Hospital, Nagpur in the Department of Pathology. A total of 300 samples were received from Department of Neurosurgery.
Materials and Methods: Detailed collection of clinical data was done in all patients regarding age, sex, clinical symptoms and radiological findings.
The samples were received in 10% formalin and subjected to routine histopathological processing. Slides prepared were stained with hematoxylin and eosin stain. Special stains were done wherever required.
Results: Total 300 cases were studied of which 261 cases (87%) were neoplastic in nature and 39 cases (13%) were non neoplastic. Amongst primary tumours, most common were gliomas (48%) followed by meningiomas (20%) and schwannomas (9%).
Conclusion: ICSOLs can present with nonspecific clinical features. Radio diagnostic investigations are helpful adjunct tools but cannot give exact diagnosis. Histopathological examination remains a gold standard for diagnosing and grading of tumours on which basis clinician can decide further line of management.

Keywords: Histomorphology, ICSOL, Glioma, Meningioma.

How to cite : Kinkhede D S, Meshram S A, Parate S N, Kumbhalkar D T, Tathe S P, Randale A A, Histomorphological spectrum of intracranial space occupying lesions: Experience at tertiary care centre. Indian J Pathol Oncol 2021;8(4):485-491

Copyright © 2021 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)

Article History

Received : 11-03-2021

Accepted : 09-08-2021

Available online : 25-11-2021

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