Ki-67 expression in human oral squamous cell carcinoma

Original Article

Author Details : Chandrakanta , Pooja Nagayach, Ritu Sonkar, Rajni Bharti, Harendra Kumar*

Volume : 8, Issue : 4, Year : 2021

Article Page : 473-477

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Introduction: Oral cancers are one of the 10 leading cancers in the world. However, in India, it is one of the most common cancers and constitutes a major public health problem. Oral squamous cell carcinoma is a well-known malignancy that accounts for more than 90% of all oral cancers.
Materials and Methods: The study is carried out on 40 biopsy samples received on oral mucosa, in Department of Pathology of our institute.
Result: Maximum numbers of patients were from 3th to 6th decade in our study. 38 cases of oral squamous cell carcinoma were observed, out of which 31 (81.57%) were male, and 07 (18.42%) cases were female. The most common site was tongue (50%), followed by buccal mucosa (18.42%), 06 patients (15.78%) had lesion at palate. Thirty-five (92.10%) cases had a significant history of tobacco use/smoking, whereas 03 (7.89%) did not have any history of tobacco use. We observed Ki-67 LI for normal oral mucosa was 14 ± 5.6%. In well-differentiated carcinoma, the KI-67 LI was 28.52 ± 21.25%, which increased to 42.85 ± 18.2% in moderately differentiated carcinoma and 68.57 ± 17.6% in poorly differentiated carcinoma.
Conclusion: Ki-67 acts as an excellent marker of cellular proliferation. There is a statistical difference in KI-67 overexpression between various grades of oral squamous cell carcinoma and normal oral mucosa (p value <0>  

Keywords: Oral cancer, Ki-67, SCC.

How to cite : Chandrakanta, Nagayach P, Sonkar R, Bharti R, Kumar H, Ki-67 expression in human oral squamous cell carcinoma. Indian J Pathol Oncol 2021;8(4):473-477

Copyright © 2021 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 15-07-2021

Accepted : 02-09-2021

Available online : 23-11-2021

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