Biochemical and haematological parameters predicting severity of Covid 19 infection: Lessons from first wave of pandemic

Original Article

Author Details : Mrunal Kesari, Yoganand V Patil, Shweta D Agrawal*, Harshad V Kesari, Priyanka V Gadge, Lalita Y Patil, Haffizunissa Rehman

Volume : 8, Issue : 3, Year : 2021

Article Page : 327-333

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Context: Corona virus disease 2019 (COVID-19) was declared as pandemic by WHO on March 10, 2020. Several countries around the globe have seen a two-wave pattern of reported cases. India is witnessing unprecedented spike in COVID-19 cases again since March 2021 especially in Maharashtra. Newer insights in pathogenesis of diseases, diagnosis and treatment modalities continue to evolve in case of novel infection.
Aim: To study and compare laboratory parameters in COVID cases in first wave in 2020.
Design: Retrospective cross-sectional observational study.
Materials and Methods: Total 400 cases; 354 RTPCR and 46 RAT confirmed cases of COVID-19 done at dedicated COVID Hospital.
Statistical Analysis: Comparison of laboratory parameters was done between 72 Severe and 328 Non-Severe cases by unpaired t-test.
Results: Statistically significant differences were seen in severe cases as compared to non severe cases in Lymphocyte count, Eosinophil count, Neutrophil Lymphocyte Ratio, CRP, D-dimer, Ferritin levels. WBC count, Platelet count and ALT did not show significant difference between severe and non severe cases.
Conclusion: Lymphopenia, raised N/L ratio, Eosinopenia, increased D-dimer, Ferritin, CRP are associated with severe COVID disease. The routine laboratory tests can diagnose the disease, predict prognosis and complications and monitor treatment response.

Keywords: COVID- 19, Laboratory parameters, RTPCR, Prognosis, Severe disease.

How to cite : Kesari M, Patil Y V, Agrawal S D, Kesari H V, Gadge P V, Patil L Y, Rehman H, Biochemical and haematological parameters predicting severity of Covid 19 infection: Lessons from first wave of pandemic. Indian J Pathol Oncol 2021;8(3):327-333

Copyright © 2021 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 10-04-2021

Accepted : 04-05-2021

Available online : 12-08-2021

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