Expression of vimentin in breast carcinoma and its correlation with histopathological parameters


Original Article

Author Details : Kumari Bhuvaneshwari A*, Vani D

Volume : 8, Issue : 2, Year : 2021

Article Page : 207-212

https://doi.org/10.18231/j.ijpo.2021.041



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Abstract

Background and Objectives: Despite various treatment and diagnostic options, Breast cancer remains one of the top cancer in women both in developed and the developing world. In such a scenario, Immunohistochemistry plays an important role in pathology of breast disease which contributes for solving diagnostic problems and for determining prognosis and response to therapy. There is growing list of IHC markers available, the present study highlights the importance of vimentin a mesenchymal marker in breast carcinoma cases.
Objectives of the Study: 1) To assess the expression of vimentin in various types of breast carcinomas. 2) To find out the correlation between expression of vimentin and prognostic markers such as tumor size, tumor grade and lymph node status.
Materials and Methods: The study included 50 cases of modified radical mastectomy specimens received in the Department of Pathology, during December 2017 to May 2019. After collecting the history, the specimens were examined, fixed in 10% formalin and sections were studied by hematoxylin and eosin and immunohistochemically.
Results: In the present study majority of the patients were in the age group of <40>

Keywords: Breast carcinoma, Lymph node status, Tumor size, Tumor grade, Vimentin.


How to cite : Kumari Bhuvaneshwari A, Vani D, Expression of vimentin in breast carcinoma and its correlation with histopathological parameters. Indian J Pathol Oncol 2021;8(2):207-212


Copyright © 2021 by author(s) and Indian J Pathol Oncol. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)



Article History

Received : 18-01-2021

Accepted : 27-01-2021

Available online : 19-05-2021


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https://doi.org/10.18231/j.ijpo.2021.041


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